Move over “Meet the Fockers” ha and meet the APOE family.
APOE genes provide instructions for making a protein called apolipoprotein E.
This protein combines with fats (lipids) in the body to form molecules called lipoproteins.
Lipoproteins are responsible for packaging cholesterol and other fats and carrying them through the bloodstream.
But APOEs can have glitches. Or variants.
An allele, or allelomorph, or “genetic glitch” - is a variant.
There are three common “variants” or “glitches of APOEs.
Each carries different levels of risk for developing Alzheimer's disease.
In other words, “APOE status” of various variants, effects our risk of keeping our wits, or diminishing them.
These major APOE alleles are called e2, e3, and e4.
The most common allele is e3, which is found in more than half of the general population. This genetic glitch of APOE has neither a protective or damaging effect on cognition. It’s a “non-influencer”.
APOE2 is protective.