Discussion about this post

User's avatar
Dr K's avatar

Great presentation! I am a A4M trained IMd. And every time I’m listening to your podcast, I do learn something new! Great topic.

I will pass along to My colleagues gynecologist, and I’m struggling still with them in regards bioHRT. Gradually trying to give them information to research and educate them.

Love your work and enthusiasm! 😊

Expand full comment
Chris McKinley's avatar

Estradiol (E2) can convert to estriol (E3) in the body. This conversion primarily occurs in the liver and, during pregnancy, in the placenta. Estradiol is metabolized into estriol as part of the body’s natural estrogen metabolism pathway.

Here’s a brief explanation of the process:

Estradiol is one of the three main estrogens in the body, alongside estrone (E1) and estriol (E3).

Estradiol can be converted to estrone through reversible enzymatic processes.

Estrone can then be further metabolized into estriol.

During pregnancy, estriol becomes the dominant estrogen due to increased production in the placenta, which synthesizes it from precursors provided by both the fetus and the mother.

Outside of pregnancy, the production of estriol is much lower, as it is considered a weaker estrogen compared to estradiol and estrone. However, the conversion still occurs as part of normal estrogen metabolism.....And YES....E3 is an important Cancer protector. It is great to give E2 and E3!!

Expand full comment
4 more comments...

No posts