Just as estrogen replacement is being vindicated, some are “dissing” estriol. And the benefit to add this estrogen (E3), into the estrogen replacement mix when using estradiol, E2.
The use of BOTH estrogens is called “Bi-est”. The “Bi” stands for “two” estrogens.
There are 3 major parent estrogens: estrone, estradiol and estriol.
The first use of bioidentical hormonal therapies used all three. Thus it was called ““Triest”.
Now, the typical use of two estrogens is often referred to as “Biest”.
Why add estriol to the estradiol mix?