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Lp(a) - Kidney & Heart Health. And... food!
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Nutrition

Lp(a) - Kidney & Heart Health. And... food!

There's much you can do yourself to try to lower this marker, if elevated.

devaki berkson's avatar
devaki berkson
Jun 02, 2024
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Lp(a) - Kidney & Heart Health. And... food!
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There is a growing appreciation that as renal function falters, heart disease becomes more possible and dangerous.

There is a molecule that is part of this newly appreciated kidney-heart link.

This comes from British researchers (Clinical Trial Service Unit & Epidemiological Studies Unit,* Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom and the Medical Research Council Population Health Research Unit,† Oxford, United Kingdom).

The new culprit? Lipoprotein (a) or called lipoprotein little a.

Lipoprotein(a), or Lp(a), is a type of fat in the body that can deposit cholesterol inside arteries. Promoting plaque.

Lp(a) is a genetically inherited risk factor for heart disease.

But we are now learning that it also can form more often in patients with kidney disease.

Lp(a)’s structure is similar to low-density lipoprotein (LDL), or "bad" cholesterol, but they are different lipoproteins with unique characteristics.

Lp(a) levels can range from less than 1 mg/dl to more than 1,000 mg/dl.

Elevated levels are correlated with cardiovascular disease. And stroke.

However, there's no evidence that mild to moderate elevations (below 50 mg/dL) lead to an elevated risk of heart disease or stroke.

The kidney has a role in keeping Lp(a) levels healthy. How? The kidney breaks down Lp(a) or oversees its catabolism.

This means that Lp(a) levels go up when kidney function goes down.

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