Parkinson's Dx - the 2nd Most Dreaded and Common Cognitive Brain Issue

The Protective Role of Estrogens

Parkinson’s disease is the second most common neurodegenerative disorder worldwide, affecting more than 10 million people. Symptoms include tremors, and problems with movement, balance, and coordination.

Experts believe it is caused by the death of dopamine-containing nerve cells in the region of the brain involved in motor control.

New research suggests that “synapses” — the connections between these nerve cells — may start to become dysfunctional before the nerve cells are affected.

Neurons from PD patients displayed “defective” recycling of synaptic vesicles, leading to the accumulation of toxic oxidized dopamine.

Protection

What protects synaptic vesicles? Estrogen. Especially in the human “memory piggy bank” - the hippocampus. In both genders.

Estrogen does this by signaling the second estrogen receptor in the brain, ER beta. Estriol also signals this, which is why replacing estriol with estradiol (two estrogens = biest) makes so much protective sense. PS. The botanicals in my Hormone Balance and Protect also signal ER beta and should be brain-boosting, too.

The research demonstrating the amazing ability of estrogen to protect our brain tissue and cognition, in both genders, continues to grow.

All the while our FDA continues to want to take bioidentical hormones off the legal to-compound list.

If you are in my PRO Level Membership group, last Tuesday evening we heard critical personal updates from the amazing Dr. Daved Rosensweet, who just got back from Washington. Pro Members can find the replay in their archives.

Warm regards and stay true to the physiologic facts.

Knowledge is power.

Dr. B.

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References:

Parkinson's disease-linked parkin mutation disrupts recycling of synaptic vesicles in human dopaminergic neurons. Neuron. 2023 Sep 13:S0896-6273(23)00629-3

https://www.medicalnewstoday.com/articles/newly-discovered-trigger-for-parkinsons-may-lead-to-better-treatment-avenues?utm_source=Sailthru%20Email&utm_medium=Email&utm_campaign=MNT%20Daily%20News&utm_content=2023-09-26&apid=25193324&rvid=80c42e8212ba47cd18161d860f53eea85fe8a264076176485d7ec0bba6702d6f

Estradiol acutely potentiates hippocampal excitatory synaptic transmission through a presynaptic mechanism. J Neurosci. 2010 Dec 1;30(48):16137-48

Estradiol in vitro modulates Na+-dependent Ca2+ uptake by synaptic plasma membrane vesicles of rat brain regions. J Endocrinol Invest. 1997 Dec;20(11):664-8