Something is WRONG with this drug picture!

Receptors under "attack", even GLP-1, and what else you might do!!!!

Glucagon-like peptide 1 (GLP-1) medications are THE TREND in medical prescribing.

But something is very wrong.

We have all forms of medical editorials calling for using these products in kids as young as 5 and in diseases from renal to heart issues, even dementia, yet this med is NOT prescribed in the country that makes it. Except for Type2 Diabetics. That have failed to improve with cheaper meds first.

Ozempic is NOT approved for weight loss in Europe at all!

Take this in… Even the Danish company that manufactures Ozempic, does not approve its use for weight loss. Without a diagnosis of type 2 diabetes. That failed cheaper meds first.

So the country that sells this to us, doesn’t use these meds.

While our drug advertising, government agencies and doctors are tripping over themselves to advertise and prescribe these to an ever widening patient base.

Americans are the ideal drug customers of the world.

America is Novo’s primary market.

Doctors just keep writing scripts and our agencies seem to keep okaying their usages, while not asking why we have so many obese.

• What’s in our food that is paralyzing our brown calorie burning fat?

• What chemicals train our fat cells to misbehave?

• Why are we not actively encouraging sane life style changes?

I am seeing article after article saying these drugs are good for this. For that.

Oh wait, let’s get Medicare to cover $15,000 a year for patients. Even though we historically worry that Medicare might be toppled by just regular meds.

If a drug goes this wide, this fast, this into the literature, into the prescription pads, into Medicare coverage, what the hell is really going on?

If you are not suspicious that something is stinking in Denmark, and this saying really applies here (Novo Nordisk makes this drug. In Denmark. While Denmark’s Danish Medicines Agency only allows Type 2 Diabetics to take this med. And only AFTER they failed to get results. From cheaper meds. NOT FOR WEIGHT LOSS!) then you are not waking up and smelling the pharmaceutical coffee beans.

Our American health agencies are NOT doing their due diligence to safeguard our health.

This Substack is a dive into semaglutide realities.

As Truth and Triage wrote so brilliantly:

Ozempic is the COVID shot of weight loss drugs.

Who knows what damage lurks just over the horizon?

What are semaglutides?

• Semaglutides are GLP-1 drugs.

• Ozempic is a brand name for a semaglutide drug.

Ozempic is a weekly injection first approved by the U.S. Food and Drug Administration (FDA) in 2017 to help lower blood sugar in adults with Type 2 diabetes by forcing the pancreas to produce more insulin.

Similar drugs are Wegovy and Rybelsus, which are also manufactured by Novo Nordisk, and Tirzepatide, branded as Mounjaro and Zepbound.

How they work.

These meds mimic a hormone in the body known as GLP-1.

A healthy gut makes its own GLP-1.

GLP-1 is released from cells in the small intestines.

GLP-1 is also released in smaller quantities by the pancreas and central nervous system.

GLP-1 helps regulate appetite, stimulates insulin secretion, inhibits glucagon secretion, and delays gastric emptying.

All these actions trick your brain into making you feel full.

These semaglutide drugs effectively decrease food intake.

They do NOT increase energy expenditure to burn off calories.

These semaglutides act on GLP-1 receptors.

These are all over the gut, but also in the brain. In the appetite center.

Semaglutides, like our own GLP-1 should do, “inform” the appetite center you are full.

• GLP-1 is a receptor.

• Our toxic environment is assaulting our various receptors.

BTW, disruption of GLP-1 receptors is being linked to lots of health issues, not just obesity. A few examples are polycystic ovarian syndrome and even infertility.

BTW yet again, endocrine disrupting chemicals (EDCs) such as persistent organic pollutants (POPs) and even MSG added to Chinese food, can damage our own natural GLP-1 receptors.

• GLP-receptors are under attack by our dirty planet (air, food, water).

• Thus, detox and reducing exposure to EDCs should be a part of ALL optimal weight maintenance programs.

Ozempic and Wegovy both contain the identical active ingredient, “semaglutide”.

Wegovy, though, is essentially Ozempic at a higher dosage. Approved for weight loss. In the US.

I have seen folks lose weight on these meds. Folks that could not get themselves to change their diets or work out enough or did all of the above yet did not lose weight.

But they lose muscle.

And still need to alter their lifestyles to keep the weight lost, off.

I think continuous glucose monitors do a similar job. These train us as to which foods are our “friend” or “foe” to our GLP-1 receptors.

Once you learn and notice which foods bump up your blood sugar, you can avoid your sugar/fat boosting foods.

Then you often lose weight just as effectively.

But also while learning better eating habits.

And perhaps adding in my receptor protective new Biotic’s products (I mention more below).

Once your stop taking semaglutides, the weight often comes back — with a vengeance.

Because taking these medications do NOT address the “root causes” as to why that individual gained weight in the first place.

Also, the longer you stay on semaglutides, the more you mess with your body’s physiology and subject yourself to a possible laundry list of nasty side effects.

This list keeps growing!

Why wouldn’t it?

Anything that our entire medical system has so rapidly jumped onto the band wagon while the country itself that makes this med has not, should warn all of us. To tread carefully.

Ozempic is a cash cow for Novo Nordisk.

Ozempic costs $1,300 for a one-month supply.

Raking in over $9.4 billion in the first 3 months of 2024 alone.

More than 4,000 social media campaigns, celebrity endorsements, glowing news coverage and monies paid out to weight loss “experts”, have convinced Americans to embrace GLP-1 (glucagon-like peptide-1) drugs. Without true regard for possible health consequences.

Oh my.

This is a tragedy waiting to happen.

Ozempic is now even being pushed on vulnerable populations like children. Without long term studies. But in America we are grooming our patients to accept this. Wow.

The American Academy of Pediatrics (AAP) now recommends weight loss drugs for obese kids.

As Truth and Triage again brilliantly states:

Children can now get their 72-plus vaccinations, irreversible puberty blockers, and weight-loss injections—all courtesy of AAP guidance unfit for even a clown.

The Illusion of Fat Loss

Ozempic causes “eating less” causing more "weight loss".

But studies show that semaglutides do not discriminate between fat and lean muscle.

Instead of mainly targeting fat, Ozempic can lessen bone density and cause significant muscle loss—problems that have long-term implications for overall health. Let alone appearance.

Sarcopenia, loss of muscle, accelerates aging.

If a person’s body mass index is in the normal or low range, but their levels of lean muscle are severely low, which can happen after semaglutide care, then fat and bones are the main metabolically active tissues that “give up the ghost”.

We lose muscle.

We lose bone.

But yes we look better in those clothes.

But what about kids that are using these meds to lose weight?

What will this due to their futures? Kid’s body’s are so unique. So much is happening. So rapidly.

We don’t know yet.

But our governmental agencies are ramping up to make this insurance reimbursable.

You gotta ask out loud, WTF?

Possible Nasty Effects

Blindness: Health officials within the European Medicines Agency announced on Dec. 17 2024 that they are reviewing two recently published independent studies that found that Ozempic significantly increases the risk of a severe eye disease: developing non-arteritic anterior ischemic optic neuropathy (NAION).

NAION is an irreversible condition that damages the optic nerve.

It can lead to severe and permanent vision loss.

Both studies are based on Danish registries. The largest in the world.

Before Ozempic came out on the med market, Danish doctors only saw 60-70 cases of NAION each year.

Now, they see up to 150. This increase is exclusive to patients with type 2 diabetes—the target market for Ozempic in Denmark.

An American study also showed that Ozempic increased the risk of NAION. This US study showed a higher number of cases than even the Danish studies.

A study published in 2022 in JAMA Network Open followed 175 patients taking semaglutides over six months. Tracking results and side effects.

Results showed a reduction in total body weight of 5.9% at three months and 10.9% at six months.

Intestinal nausea to paralysis: But, nearly half of the patients (85 out of 175) reported adverse effects, which included: gastrointestinal symptoms, nausea, vomiting, diarrhea, and fatigue.

When I shadowed Dr. Sam in LA, for 2 days there were 2 patients who had such severe intestinal paralysis they had ended up in the hospital. Months later were still in pain.

They were lean type2 Diabetics prescribed these meds for blood sugar control.

A 2022 study published in the New England Journal of Medicine found that overweight or obese participants who took 2.4 mg of semaglutide once weekly, in addition to lifestyle changes, experienced a sustained reduction in body weight.

Yes they lost weight.

However, people in the semaglutide group (compared to placebo) experienced nausea and diarrhea, and 59 participants, compared to only five in the placebo group, experienced mild to severe gastrointestinal events.

Almost all studies show that Wegovy, and drugs like it, need to be taken long-term.

What will be the results from long term use?

We don’t know yet.

But the Danish and Europeans aren’t jumping to use these meds long term. Let alone short term.

Another issue is taking these with surgery.

In patients undergoing surgery that requires anesthesia, GLP-1s can increase the risk of pulmonary aspiration. This can cause aspiration pneumonia.

This was published in July 2024 in the journal Gastroenterology.

Routine fasting before a surgery doesn’t seem to be enough.

It’s suggested that patients stop these medications at least 1 week prior to surgery.

Ozempic Carries FDA’s Highest Safety Warning

Thyroid issues: According to Wegovy’s website, both Wegovy and Ozempic have caused thyroid C-cell tumors, including thyroid cancer, in studies with rodents!

Because of this, our FDA has put “black box warnings” on both Wegovy and Ozempic — the highest safety-related warnings the FDA can assign to medications.

Whether the drugs can cause thyroid tumors or cancer in people is unknown because it has not been thoroughly studied.

I am a DES daughter. Many of us could not have kids. Had cancers.

The drug companies saw that DES caused tumors in rodents. Yet they launched these meds from 1938 to 1971 for pregnant women.

Consumer beware!

Studies suggesting the opposite, that taking semaglutides do not increase the risk of thyroid cancers are often conflicted and flawed.

Not all science, these past few years have clearly taught us, is scientific.

In a November 2022 study by the American Diabetes Association, researchers found an increased risk of “all” thyroid cancers and medullary thyroid cancer with the use of GLP-1 receptor agonists, in particular after 1–3 years of treatment.

This should give us all pause.

GLP-1 receptors are expressed all throughout thyroid tissues. (Not just the gut and the brain appetite centers)

Many Americans have thyroid disease already.

Should we be screened and avoid these semaglutides if we already are on thyroid meds?

Other possible serious side effects include:

• Acute Kidney damage and failure.

• Intestinal paralysis and pain.

• Severe constipation.

• Gallbladder problems.

• Inflammation of the pancreas.

• Hypoglycemia (low blood sugar).

• Nervous system disorders.

• Vision changes.

• Persistent suicidal thoughts with increased severity with higher doses.

• Thyroid dysfunction for those taking thyroid medications

According to the package insert for Wegovy, this med can cause acute gallbladder disease. “Especially in kids”.

Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, was observed in patients treated with semaglutide and in patients treated with Wegovy during clinical trials.

Suicidal Behavior? According to its manufacturing company, Novo Nordisk, suicidal behavior and ideation, worsening depression, and unusual changes in mood and behavior have been reported.

The European Medicines Agency announced in July 2024 that it was reviewing 150 reports of self-injury and suicidal thoughts from people who took GLP-1 receptor agonists, such as Ozempic and Wegovy.

The UK’s Medicines and Healthcare products Regulatory Agency is reviewing similar reports.

Wegovy’s package insert carries a warning about suicidal thoughts because the FDA requires medications for weight management that affect the central nervous system to carry a warning, but the agency has “not” added the warning to Ozempic.

Our adverse events tracking system:

• Among the most popular weight loss drugs—including Ozempic, Wegovy, Saxenda, and Semaglutide—50,144 adverse events have been reported.

• 19,302 classified as serious.

• And 571 fatalities!

Docs are being groomed.

A Reuters special report found Novo Nordisk spent $25.8 million over the past decade convincing U.S. medical professionals to promote Wegovy and Saxendra.

At least 57 U.S. physicians individually accepted at least $100,000 from Novo Nordisk in payments associated with Wegovy or Saxenda over the same period, and these weren’t just any doctors.

41% were obesity specialists who run weight-management clinics, work at academic hospitals, write obesity-treatment guidelines, or hold top positions at medical societies.

Worst Sign of All that Something Stinks in Denmark

Our good ole’ US government, who seems very much in bed with Big Pharma, seems eager to join in.

Wegovy has already been approved for use in children as young as 12, and some are pushing to make these drugs available to kids as young as 6.

As Truth and Triage states:

We’re now considering injecting children with drugs that have black box warnings for thyroid tumors to combat a problem that could be addressed with proper nutrition and exercise.

If you don’t wonder about our governmental agencies and their relationship with pharmaceutical giants, then your head is in the sand.

Our agencies are not just about protecting us.

They are now about pushing meds.

Children’s bodies are rapidly still developing.

The impact of drugs like semaglutide on growth, hormonal balance, and mental health remains largely unknown.

If you don’t wonder about what the heck is going on, you might be in a toxic American food coma to care.

We are so much into these medications, Medscape had an entire article guiding doctors on which OTC products to guide patients to purchase to offset the almost inevitable side effects.

YEECH.

Prescribed and Over-the-Counter Medication Interventions

Doctors can also prescribe certain medications to help patients manage side effects including prucalopride, which can be used off-label to help with constipation, said Ali Rezaie, MD, a gastroenterologist at Cedars Sinai in Los Angeles.

Other medications, including metoclopramide, can help with symptoms of slow gastric emptying, or gastroparesis.

And for nausea, the most common complaint, prescribed medications like ondansetron and domperidone, can help as can some over-the-counter medications like Dramamine.

When a drug that is made by one country is mostly marketed in another country but not the manufacturing one, and it goes so far, so fast, so wide spread, you gotta say, “Follow the money”.

I had one patient whose whole family all weighed over 300 lbs.

She had never lost a huge amount of weight.

Never went under 300 lbs.

My new products by Biotic’s sensitize hormone receptors, including insulin.

The patient feed back has shown that they act like gentle, natural semaglutides.

We got her hormones balanced, put her on Receptor Detox (2 BID but 4 BID on Detox Weekends) and Hormone Balance and Protect (5/d as she weighed so much), and now she has been under 150 lbs for several years.

And is winning athletic competitions.

One doctor using my products had a patient that could never lose her last 5 pounds.

She did this and that. To no avail.

He put her on these products along with just one Detox weekend (4 Receptor Detox BID with food Saturday and Sunday, eating mainly organic) and within 4 weeks, this doc called up his Biotic’s rep.

He said to tell me she lost that last 5 pounds.

And to thank me.

Makes it all worth it.

Knowledge is power.

If something seems too good to be true and is now being prescribed too far and too wide, proceed with caution.

It’s always better to try to do things naturally.

Make life style changes.

Use nutraceuticals rather than pharmaceuticals.

Be wary of walletectomies with new products from other countries that aren’t even used for the same usages way over there.

Get real.

Get safe.

Get healthy.

Dr. B.

References:

The endocrine disrupting potential of monosodium glutamate (MSG) on secretion of the glucagon-like peptide-1 (GLP-1) gut hormone and GLP-1 receptor interaction. Toxicol Lett. 2017 Jan 4;265:97-105

https://www.TruthandTriage.com

Expert Tips for Managing GLP-1 Medication Side Effects - Medscape - December 27, 2024.