Testosterone

Ways to improve T levels without direct testosterone replacement.

Ways to improve without direct testosterone replacement:

• B-vital by Biotics

• Plus D-Chiro-Inositol (helps with T plus lowers E)

Background:

Several recent journal articles report that D-chiro-inositol (DCI), primarily known as insulin’s second messenger, influences steroidogenesis. In particular, there is new evidence of DCI’s ability to regulate aromatase expression and testosterone biosynthesis.

In this regard, DCI administration could represent a good therapeutic opportunity in case of reduced levels of testosterone.

It is odd that it helps PCOS ladies, and also low-T gents. Go figure.

We call something that raises what is too low, and lowers what is too high, an adaptogen.

In this manner, DCI might be thought of an a “testosterone adaptogen”.

Older men generally have lower testosterone concentrations than younger men, and recent randomized controlled trials have examined whether testosterone treatment might improve health outcomes in this age group.

Results:

Ten older men with basal low testosterone levels were enrolled in this study. Patients took 600 mg of DCI, two times per day, for 30 days.

We evaluated hormonal and glycaemic parameters, weight, waist circumference, and Body-Mass Index at baseline (T0) and after 30 days (T1).

Finally, all patients also filled in the standardized International Index of Erectile Function questionnaire and performed the Handgrip test at T0 and T1.

Men receiving DCI showed "increased androgen" and "reduced oestrogen" concentrations, and improved glycaemic profiles.

DCI was also associated with reduced weight, Body-Mass Index, waist circumference, improved grip strength, and self-reported sexual function. All these effects led to the improvement of sexual function and physical strength.

Conclusions:

In this pilot study, DCI treatment improved testosterone and androstenedione levels at the expense of oestrogens in elder men with low basal levels of these hormones without adverse effects.

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Reference:

D-Chiro-Inositol improves testosterone levels in older hypogonadal men with low-normal testosterone: a pilot study. Basic Clin Androl. 2021 Nov 12;31(1):28. DOI: 10.1186/s12610-021-00146-4. PMID: 34763665; PMCID: PMC8588714.